Thymic deficiency in Down's syndrome.
Pediatrics
; 63(1): 80-7, 1979 Jan.
Article
em En
| MEDLINE
| ID: mdl-155804
ABSTRACT
Children with Down's syndrome (DS) often have small and abnormal thymuses, with lymphocyte depletion, diminution of the cortex, and loss of corticomedullary demarcation--a picture resembling thymic involution. Besides this, they have markedly enlarged Hassall's corpuscles, some surrounded by a sheath of lymphocytes. Patients with DS are known to have increased numbers of respiratory infections; they also have a higher incidence of lymphatic leukemia than do individuals who do not have DS. Studies of cell-mediated (thymic-dependent) immunity demonstrate that children with DS have both diminished numbers of T cells as well as functional deficiency of these cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Síndrome de Down
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article