Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.

Bruncko, Milan; McClellan, William J; Wendt, Michael D; Sauer, Daryl R; Geyer, Andrew; Dalton, Christopher R; Kaminski, Michele A; Weitzberg, Moshe; Gong, Jane; Dellaria, Joseph F; Mantei, Robert; Zhao, Xumiao; Nienaber, Vicki L; Stewart, Kent; Klinghofer, Vered; Bouska, Jennifer; Rockway, Todd W; Giranda, Vincent L

Bruncko, Milan; McClellan, William J; Wendt, Michael D; Sauer, Daryl R; Geyer, Andrew; Dalton, Christopher R; Kaminski, Michele A; Weitzberg, Moshe; Gong, Jane; Dellaria, Joseph F; Mantei, Robert; Zhao, Xumiao; Nienaber, Vicki L; Stewart, Kent; Klinghofer, Vered; Bouska, Jennifer; Rockway, Todd W; Giranda, Vincent L.

Afiliação

Bruncko M; Cancer Research, Global Pharmaceutical R&D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. milan.bruncko@abbott.com

Bioorg Med Chem Lett ; 15(1): 93-8, 2005 Jan 03.

Article em En | MEDLINE | ID: mdl-15582418

ABSTRACT

ABSTRACT

A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.

Assuntos

Naftalenos/farmacocinética; Inativadores de Plasminogênio/farmacocinética; Ativador de Plasminogênio Tipo Uroquinase/antagonistas & inibidores; Modelos Moleculares; Naftalenos/química; Inativadores de Plasminogênio/química; Especificidade por Substrato

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativador de Plasminogênio Tipo Uroquinase / Inativadores de Plasminogênio / Naftalenos Idioma: En Ano de publicação: 2005 Tipo de documento: Article

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