TB, or not TB: that is the question -- does TLR signaling hold the answer?
J Clin Invest
; 114(12): 1699-703, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15599394
Innate immunity critically depends on signaling by Toll-like receptors (TLRs) that rely heavily on an intracellular adapter protein called myeloid differentiation factor 88 (MyD88). Adaptive immune defenses are generally thought to be orchestrated by innate immune responses and so should require intact TLR-MyD88 signaling pathways. But a surprising new study in MyD88-null mice infected with Mycobacterium tuberculosis challenges this view and instead suggests that MyD88 may not be absolutely required for a normal adaptive immune response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Glicoproteínas de Membrana
/
Receptores Imunológicos
/
Antígenos de Diferenciação
/
Receptores de Superfície Celular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article