[Genetic polymorphisms of 6 Y-chromosome specific STR loci in the southern Chinese Han population and its application in forensic science].
Yi Chuan
; 26(4): 446-50, 2004 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-15640037
ABSTRACT
To study the genetic polymorphisms of six Y-chromosome specific STR loci in the southern Chinese Han population and apply it in forensic science, six Y-STR loci were amplified by multiple PCR and the PCR products were detected by using ABI Prism 377 Sequencer. The haplotype frequencies at 6 Y-STR loci were determined in a total of 204 unrelated males from southern Han population of China. Ninety-three father/son pairs with demonstrated paternity and thirty-eight non-paternity father/son pairs were detected by using our Y-STR system. As a result, the number of alleles for DYS393, DYS19, DYS389 II, DYS390, DYS391 and DYS385 were 5, 6, 8, 6, 4 and 44, respectively. A total of 176 haplotypes at 6 Y-STR loci were found. Two father/son pairs with single Y-STR mutation were observed in the 93 father/son pairs with demonstrated paternity. Among the 38 non-paternity father/son pairs, one case with one Y-STR exclusion of paternity, one case with two Y-STR exclusions and 35 cases with 3 or more Y-STR exclusions were observed. Non-exclusion of paternity at 6 Y-STR loci was found only in one case. This result indicated that the six Y-STR loci were highly polymorphic and are suitable for personal identification and paternity testing.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paternidade
/
Polimorfismo Genético
/
Haplótipos
/
Cromossomos Humanos Y
Limite:
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2004
Tipo de documento:
Article