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The ARF tumor suppressor: keeping Myc on a leash.
Gregory, Mark A; Qi, Ying; Hann, Stephen R.
Afiliação
  • Gregory MA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2175, USA.
Cell Cycle ; 4(2): 249-52, 2005 Feb.
Article em En | MEDLINE | ID: mdl-15655352
The ARF tumor suppressor protein acts in a checkpoint that guards against unscheduled cellular proliferation in response to oncogenic signaling. Deregulated expression of c-Myc induces ARF expression and apoptosis through the ARF-Mdm2-p53 axis. Our recent study reveals a new direct role for ARF in controlling c-Myc's oncogenic activity that is independent of p53. ARF binds to and selectively impairs the transactivation ability of c-Myc while leaving its transrepression ability intact. Biologically, ARF prevents hyper-proliferation and transformation caused by c-Myc and enhances c-Myc-induced apoptosis independently of p53. These new findings may be especially relevant for therapeutic strategies targeting c-Myc-induced cancers.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-myc / Proteína Supressora de Tumor p14ARF / Proliferação de Células Limite: Animals / Humans Idioma: En Ano de publicação: 2005 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-myc / Proteína Supressora de Tumor p14ARF / Proliferação de Células Limite: Animals / Humans Idioma: En Ano de publicação: 2005 Tipo de documento: Article