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Asymptomatic systemic sarcoidosis arising 5 years after IFN-alpha treatment for chronic hepatitis C: a new challenge for clinicians.
Tortorella, Cosimo; Napoli, Nicola; Panella, Elisabetta; Antonaci, Alessandra; Gentile, Antonia; Antonaci, Salvatore.
Afiliação
  • Tortorella C; Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy. c.tortorella@intmed.uniba.it
J Interferon Cytokine Res ; 24(11): 655-8, 2004 Nov.
Article em En | MEDLINE | ID: mdl-15684818
ABSTRACT
Interferon (IFN)-induced sarcoidosis is well documented. Herein, we report the case of a patient with chronic hepatitis C (CHC) who developed IFN-alpha-induced sarcoidosis. The clinical features of this case make it unique among all cases so far described. The patient was, in fact, asymptomatic for sarcoidosis, and the disease, characterized by liver and lung granulomatosis, was discovered by chance during the CHC follow-up. The diagnosis was made 5 years after IFN-alpha discontinuation. A pathogenetic role for IFN-alpha in our patient is supported by a liver biopsy performed before the therapy with IFN-alpha was started, showing no evidence of granulomatous localizations. This case suggests that the incidence of sarcoidosis during IFN-alpha treatment is underestimated. A search for clinical and laboratory findings typical of the disease, as well as a liver biopsy, should always be included in the follow-up of CHC patients undergoing therapy with IFN-alpha.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoidose / Interferon-alfa / Hepatite C Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoidose / Interferon-alfa / Hepatite C Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2004 Tipo de documento: Article