The expression of human antimicrobial peptide LL-37 in the human nasal mucosa.
Am J Rhinol
; 18(6): 381-5, 2004.
Article
em En
| MEDLINE
| ID: mdl-15706986
ABSTRACT
BACKGROUND:
LL-37, an antimicrobial peptide, has been discovered to be produced by a number of epithelial cells. It is identified as a key element in the innate host defense mechanism. Because little is known about the expression of LL-37 in human sinonasal tract, we conducted this study to investigate the expression of LL-37 in human nasal mucosa.METHODS:
We investigated the expression of LL-37 gene by the reverse transcription polymerase chain reaction (RT-PCR) and localization of LL-37 peptide by immunohistochemistry in the inferior turbinate mucosa of 7 normal subjects and the nasal polyps of 12 patients with chronic paranasal sinusitis.RESULTS:
The transcripts of the LL-37 gene were detected in all human nasal tissues analyzed by RT-PCR. There is a significant increase of LL-37 mRNA expression in nasal polyps as compared with the normal nasal mucosa. Using immunohistochemistry, LL-37 peptide was localized in surface epithelial cells and submucosal glands.CONCLUSIONS:
Our findings suggest that LL-37 is expressed by nasal mucosa and is upregulated during inflammation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Conchas Nasais
/
Pólipos Nasais
/
Peptídeos Catiônicos Antimicrobianos
/
Mucosa Nasal
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article