Genomic discovery reveals a molecular system for resistance to oxidative and endoplasmic reticulum stress in cultured glioma.
Arch Neurol
; 62(2): 233-6, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-15710851
ABSTRACT
Oxygen is required for respiration and the energetic processes that enable aerobic life. Reactive oxygen species and free radicals, by-products of oxygen use, cause DNA damage and induce endoplasmic reticulum (ER) stress and apoptosis. However, rapidly multiplying cancer cells are resistant to ER and oxidative stress-induced apoptosis. The present article reports the results of highly specific genome-scale expression discovery used to identify genes differentially expressed in cultured glioma cells vs normal brain tissue. The discovered states of expression reveal a cohesive molecular system that protects rapidly growing glioma cells from ER and oxidative stress-induced apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Retículo Endoplasmático
/
Glioma
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article