Chronic hepatitis C. Genotypes and response to anti-viral therapy among Saudi patients.
Saudi Med J
; 25(12): 1935-8, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15711670
ABSTRACT
OBJECTIVE:
The aim of this study is to compare the response of hepatitis C virus (HCV) genotype 4 with other genotypes to anti-viral treatment among Saudi patients in a prospective randomized trial.METHODS:
The study was conducted in the Department of Hepatobiliary Sciences at King Abdul-Aziz Medical City, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia from March 1997 to January 2000. Sixty-two patients (33 males and 29 females) aged > or =18 with chronic hepatitis C not treated previously were tested for HCV genotype and randomly assigned to receive interferon (IFN) alfa 2b 3 million units 3 times per week alone or in combination with ribavirin 1000-1200 mg orally per day for 48 weeks. All patients were monitored for safety and efficacy of the therapy at 4 week intervals during treatment and followed up for at least 24 weeks after completion of treatment. The primary end point was loss of detectable HCV-RNA 24 weeks after treatment completion, defined as sustained virological response (SVR).RESULTS:
Hepatitis C virus genotype 4 was seen among (64.5%) HCV Saudi patients. Hepatitis C virus genotype 1 was the next most common (30.6%). A SVR of 42.8% (9 out of 21) was seen in HCV genotype 4 and 40% (4 out of 10) among other HCV genotypes with combination therapy of IFN and ribavirin (p>0.1). With IFN alone the sustained response rate was 15.7% for genotype 4 and 16.6% for other genotypes mainly genotype 1 (p>0.1).CONCLUSION:
We concluded that HCV genotype 4 is the most prevalent genotype among HCV infected Saudi patients. Genotype 1 was the next most common while genotypes 2, 3 and 5 were least prevalent. There is no statistically significant difference in response rate of patients with HCV genotype 4 to either IFN alone or IFN plus ribavirin when compared with genotype 1 of HCV.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ribavirina
/
Interferon-alfa
/
Hepacivirus
/
Hepatite C Crônica
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article