Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.
Antimicrob Agents Chemother
; 49(3): 1213-5, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15728931
ABSTRACT
The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Fatores de Transcrição
/
Candida albicans
/
Proteínas Fúngicas
/
Regulação Fúngica da Expressão Gênica
/
Proteínas de Ligação a DNA
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article