Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
Bioorg Med Chem Lett
; 15(6): 1553-6, 2005 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-15745795
ABSTRACT
HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase identified two 168 member N-acyl pyrrolidine combinatorial mixture hits. Deconvolution and expansion of these mixtures by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
RNA Polimerase Dependente de RNA
/
Hepacivirus
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article