Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists.
Bioorg Med Chem Lett
; 15(6): 1749-53, 2005 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-15745833
ABSTRACT
The chemoattractant receptor-homologous molecule expressed on T(H)2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D2 receptor involved in the recruitment of these cell types during an inflammatory response. In this report, we describe the synthesis and optimization of a ramatroban isostere that is a selective and potent antagonist of CRTH-2 which may be useful in the treatment of certain diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Carbazóis
/
Receptores de Prostaglandina
/
Receptores Imunológicos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article