A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: the EXPO study.
Aliment Pharmacol Ther
; 21(6): 739-46, 2005 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-15771760
ABSTRACT
AIM:
To assess the efficacy of the 8-week therapy with esomeprazole 40 mg vs. pantoprazole 40 mg for healing erosive oesophagitis (EE) as part of a management study.METHODS:
Patients had a history of gastro-oesophageal reflux disease symptoms (> or =6 months) and had suffered heartburn on at least 4 of the 7 days preceding enrollment. Endoscopies were performed to grade EE severity using the Los Angeles (LA) classification system at baseline, 4 and 8 weeks (if unhealed at 4 weeks). Heartburn severity was recorded by patients on diary cards. The primary end point was healing of EE by week 8 of treatment.RESULTS:
Of 3170 patients randomized, the intent-to-treat population consisted of 3151 patients (63% male, mean age 50.6 years, 27% Helicobacter pylori-positive). Esomeprazole 40 mg healed a significantly greater proportion of EE patients than pantoprazole 40 mg at both 4 weeks (life table estimates esomeprazole 81%, pantoprazole 75%, P < 0.001) and 8 weeks (life table estimates esomeprazole 96%, pantoprazole 92%, P < 0.001). The median time to reach sustained heartburn resolution was 6 days in patients receiving esomeprazole and 8 days with pantoprazole (P < 0.001).CONCLUSION:
Esomeprazole 40 mg is more effective than pantoprazole 40 mg for healing EE and providing resolution of associated heartburn.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfóxidos
/
Benzimidazóis
/
Esofagite
/
Esomeprazol
/
Antiulcerosos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article