Fluorescent metal ion indicators based on benzoannelated crown systems: a green fluorescent indicator for intracellular sodium ions.
Bioorg Med Chem Lett
; 15(7): 1851-5, 2005 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-15780620
ABSTRACT
The synthesis and metal binding properties of cation-sensitive fluorescent indicators intended for biological applications are described. The increase of the crown ether ring size enhances the affinity for larger cations, but weakens the fluorescent response and selectivity. A compound having a 15-crown-5 chelator directly attached to a 2,7-difluoroxanthenone fluorophore loads into live cells and responds to sodium ion concentration changes with large fluorescence increases in the visible wavelength range.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sódio
/
Quelantes
/
Proteínas de Fluorescência Verde
/
Corantes Fluorescentes
/
Líquido Intracelular
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article