Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening.
Neurology
; 64(6): 1076-7, 2005 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-15781834
ABSTRACT
This study describes the natural course of vincristine-induced peripheral neuropathy in patients with lymphoma (n = 114) receiving vincristine in two different dose intensities. Neuropathic changes were observed in both dose intensity groups, but the higher dose intensity group reported significantly more symptoms during therapy, whereas neurologic signs were significantly more prominent after a cumulative dose of 12 mg vincristine. Furthermore, off-therapy worsening of symptoms (24%) and signs (30%) occurred unexpectedly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervos Periféricos
/
Vincristina
/
Doenças do Sistema Nervoso Periférico
/
Linfoma
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article