Cycloruthenated primary and secondary amines as efficient catalyst precursors for asymmetric transfer hydrogenation.
Org Lett
; 7(7): 1247-50, 2005 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-15787478
ABSTRACT
[reaction see text] Ruthenacycles obtained by cyclometalation of enantiopure aromatic primary or secondary amines with [(eta6-benzene)RuCl2]2 or with [(eta6-p-cymene)RuCl2]2 are efficient catalysts for asymmetric transfer hydrogenation (TOF up to 190 h(-1) at room temperature). Enantioselectivities in the transfer hydrogenation of acetophenone ranged from 38% to 89%. It is possible to prepare the catalysts in situ, which allows the use of high throughput experimentation.
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MEDLINE
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En
Ano de publicação:
2005
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Article