A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 819(1): 175-9, 2005 May 05.
Article
em En
| MEDLINE
| ID: mdl-15797536
ABSTRACT
A robust, rapid, selective and sensitive liquid chromatography-negative atmospheric pressure chemical ionization (LC-(APCI(-))-MS-MS) method has been developed for the quantification of mometasone furoate (MF) in human plasma utilizing a solid-phase extraction clean-up step and 13C-fluticasone propionate as internal standard. The intra- and inter-day coefficients of variation were < or = 15% and the lower limit of quantification (LLOQ) was 15 pg/ml. This method is ideally suited for pharmacokinetic investigations of low MF levels following inhalation of MF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnadienodiois
/
Espectrometria de Massas
/
Cromatografia Líquida de Alta Pressão
/
Anti-Inflamatórios
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article