RP 62203, a 5-hydroxytryptamine2 antagonist, enhances deep NREM sleep in rats.
Sleep
; 15(2): 119-24, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1579785
ABSTRACT
RP 62203, a naphtosultam derivative, is an antagonist at the 5-hydroxytryptamine2 (HT2) receptor. The sleep pattern of rats treated orally with RP 62203 was studied at doses ranging from 0.5 to 4 mg/kg. Following RP 62203 administration, the duration of deep nonrapid eye movement (NREM) sleep was found to increase at the expense of wakefulness in a dose-dependent manner from 0.5 mg/kg. The 5-HT2 receptor agonist DOI and the 5-HT1a receptor agonist 8 OH-DPAT induced a dose-related increase in wakefulness; treatment with RP 62203 reversed the enhancement of wakefulness produced by DOI but not that produced by 8 OH-DPAT. These data provide further evidence for the involvement of 5-HT2 receptors in the regulation of NREM sleep in rats. RP 62203 could therefore be of clinical interest in the management of sleep disorders, particularly those developing within a psychiatric context.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fases do Sono
/
Receptores de Serotonina
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Óxidos S-Cíclicos
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Naftalenos
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article