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TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
Marie, Julien C; Letterio, John J; Gavin, Marc; Rudensky, Alexander Y.
Afiliação
  • Marie JC; Department of Immunology, University of Washington, Seattle, WA 98195, USA.
J Exp Med ; 201(7): 1061-7, 2005 Apr 04.
Article em En | MEDLINE | ID: mdl-15809351
Transforming growth factor (TGF)-beta1 is a major pluripotential cytokine with a pronounced immunosuppressive effect and its deficiency results in lethal autoimmunity in mice. However, mechanisms of its immunosuppressive action are not completely understood. Here, we report that TGF-beta1 supports the maintenance of Foxp3 expression, regulatory function, and homeostasis in peripheral CD4(+)CD25(+) regulatory T (T reg) cells, but is not required for their thymic development. We found that in 8-10-d-old TGF-beta1-deficient mice, peripheral, but not thymic, T reg cells are significantly reduced in numbers. Moreover, our experiments suggest that a defect in TGF-beta-mediated signaling in T reg cells is associated with a decrease in Foxp3 expression and suppressor activity. Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Linfócitos T CD4-Positivos / Transdução de Sinais / Fator de Crescimento Transformador beta / Proteínas de Ligação a DNA / Tolerância Imunológica Limite: Animals Idioma: En Ano de publicação: 2005 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Linfócitos T CD4-Positivos / Transdução de Sinais / Fator de Crescimento Transformador beta / Proteínas de Ligação a DNA / Tolerância Imunológica Limite: Animals Idioma: En Ano de publicação: 2005 Tipo de documento: Article