Cell cycle in mouse development.
Oncogene
; 24(17): 2877-98, 2005 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-15838522
ABSTRACT
Mice likely represent the most-studied mammalian organism, except for humans. Genetic engineering in embryonic stem cells has allowed derivation of mouse strains lacking particular cell cycle proteins. Analyses of these mutant mice, and cells derived from them, facilitated the studies of the functions of cell cycle apparatus at the organismal and cellular levels. In this review, we give some background about the cell cycle progression during mouse development. We next discuss some insights about in vivo functions of the cell cycle proteins, gleaned from mouse knockout experiments. Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Desenvolvimento Embrionário
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article