Effects of {2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose} on human hepatocellular carcinoma cell line.
Acta Pharmacol Sin
; 26(5): 635-40, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15842786
ABSTRACT
AIM:
To study the effects of {2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose (COPADG) on cultured human hepatocellular carcinoma cells (HepG2).METHODS:
HepG2 cells were cultured in RPMI-1640 medium. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry.RESULTS:
At the concentration ranging between 1-30 micromol/L, COPADG potently inhibited the growth and induced apoptosis of HepG2 cells.CONCLUSION:
COPADG could effectively induce apoptosis in human hepatocellular carcinoma cells. More investigations are warranted for the potential use of this compound as a new agent for the non-surgical management of human hepatocellular carcinoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Carcinoma Hepatocelular
/
Desoxiglucose
/
Neoplasias Hepáticas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article