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The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans.
Denver, Dee R; Morris, Krystalynne; Streelman, J Todd; Kim, Stuart K; Lynch, Michael; Thomas, W Kelley.
Afiliação
  • Denver DR; Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. d.denver@massey.ac.nz
Nat Genet ; 37(5): 544-8, 2005 May.
Article em En | MEDLINE | ID: mdl-15852004
The evolutionary importance of gene-expression divergence is unclear: some studies suggest that it is an important mechanism for evolution by natural selection, whereas others claim that most between-species regulatory changes are neutral or nearly neutral. We examined global transcriptional divergence patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to provide insights into the evolutionary importance of transcriptional variation and to discriminate between the forces of mutation and natural selection in shaping the evolution of gene expression. We detected the effects of selection on transcriptional divergence patterns and characterized them with respect to coexpressed gene sets, chromosomal clustering of expression changes and functional gene categories. We directly compared observed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neutral model of transcriptome evolution to show that strong stabilizing selection dominates the evolution of transcriptional change for thousands of C. elegans expressed sequences.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Transcrição Gênica / Caenorhabditis elegans / Mutação Limite: Animals Idioma: En Ano de publicação: 2005 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Transcrição Gênica / Caenorhabditis elegans / Mutação Limite: Animals Idioma: En Ano de publicação: 2005 Tipo de documento: Article