Epigenetic status of human embryonic stem cells.
Nat Genet
; 37(6): 585-7, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15864307
ABSTRACT
We examined the allele-specific expression of six imprinted genes and the methylation profiles of three imprinting control regions to assess the epigenetic status of human embryonic stem cells. We identified generally monoallelic gene expression and normal methylation patterns. During prolonged passage, one cell line became biallelic with respect to H19, but without loss of the gametic methylation imprint. These data argue for a substantial degree of epigenetic stability in human embryonic stem cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Impressão Genômica
/
Epigênese Genética
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article