Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.
Neuron
; 46(3): 413-20, 2005 May 05.
Article
em En
| MEDLINE
| ID: mdl-15882641
ABSTRACT
Vision in dim light requires that photons absorbed by rod photoreceptors evoke signals that reliably propagate through the retina. We investigated how a perturbation in rod physiology affects propagation of those signals in the retina and ultimately visual sensitivity. Recoverin is a protein in rods that prolongs phototransduction and enhances visual sensitivity. It is not present in neurons postsynaptic to rods, yet we found that light-evoked responses of rod bipolar and ganglion cells were shortened when measured in recoverin-deficient retinas. Unexpectedly, the effect of recoverin on postsynaptic signals could not be explained by its effect on phototransduction. Instead, it is an effect of recoverin downstream of phototransduction in rods that prolongs signal transmission and enhances visual sensitivity. An important implication of our findings is that the recovery phase of the rod photoresponse does not contribute significantly to visual sensitivity near absolute threshold.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Visão Ocular
/
Proteínas de Ligação ao Cálcio
/
Células Fotorreceptoras Retinianas Bastonetes
/
Proteínas do Olho
/
Lipoproteínas
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article