Vascular endothelial growth factor is regulated by hypoxic stress via MAPK and HIF-1 alpha in the inner ear.
J Neuroimmunol
; 163(1-2): 84-91, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15885310
ABSTRACT
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The iron-chelator desferrioxamine (DFX) increased the expression of hypoxia-inducible factor (HIF)-1alpha in the hair cell line, HEI-OC1. The increased VEGF production by DFX was inhibited by iron. DFX also induced the activation of mitogen-activated protein kinase (MAPK) on HEI-OC1. The increased VEGF production by DFX was inhibited by a specific inhibitor of MAPK. In addition, DFX induced the VEGF production and HIF-1alpha stabilization in vivo. These results indicate that VEGF production is regulated via MAPK and HIF-1alpha under hypoxic condition in the inner ear.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Fatores de Transcrição
/
Proteínas Nucleares
/
Proteínas Quinases Ativadas por Mitógeno
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Fator A de Crescimento do Endotélio Vascular
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Proteínas de Ligação a DNA
/
Orelha Interna
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article