Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals.
Metabolism
; 41(5): 526-32, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1588833
ABSTRACT
Guanidino compound levels were quantitatively determined in serum, urine, liver, kidney, and brain of man and of some ureotelic animals. The guanidino compounds were separated over a cation exchange resin, using sodium citrate buffers, and detected with the fluorescence ninhydrin method. Species-specific differences in the levels of some guanidino compounds in the studied ureotelic animals are shown. alpha-Keto-delta-guanidinovaleric acid is a naturally occurring guanidino compound in ureotelic animals, and is not restricted to the pathobiochemistry of hyperargininemic patients. The fasting serum levels observed in beagles are the same as those found in hyperargininemic patients. In serum, liver, and kidney, the homoarginine, beta-guanidinopropionic acid, and gamma-guanidinobutyric acid levels are the highest in rats. The last two compounds have the highest levels of the studied guanidino compounds, with the exception of creatinine, in kidney. Specific high levels of gamma-guanidinobutyric acid and argininic acid are found in brain of rabbits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureia
/
Encéfalo
/
Guanidinas
/
Rim
/
Fígado
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Nitrogênio
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article