MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Cancer Cell
; 7(5): 485-96, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15894268
ABSTRACT
We developed a rodent model that mimics the osteoblastic and osteolytic changes associated with human metastatic prostate cancer. Microarray analysis identified MMP-7, cathepsin-K, and apolipoprotein D as being upregulated at the tumor-bone interface. MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation. MMP-7-deficient mice demonstrated reduced prostate tumor-induced osteolysis and RANKL processing. This study suggests that inhibition of MMP-7 will have therapeutic benefit in the treatment of prostate cancer-induced osteolysis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteólise
/
Neoplasias da Próstata
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Metaloproteinase 7 da Matriz
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article