Effects of tibolone on selectins in postmenopausal women.
Maturitas
; 53(2): 166-70, 2006 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-15894441
ABSTRACT
OBJECTIVE:
The first step in atherosclerosis is characterized by the adherence of lymphocytes and monocytes to cell adhesion molecules expressed by endothelial cells. The precise mechanism by which steroid hormones may be exerting a protective action against atherogenesis remains unclear. Therefore, we wanted to investigate the effect of tibolone on the circulating levels of various selectins in postmenopausal women.METHODS:
Thirty healthy postmenopausal women were enrolled in a prospective, randomized, double blind, placebo-controlled outpatient trial.RESULTS:
Patients treated with tibolone revealed a significant decrease for the variables sE-selectin, sL-selectin, and sPECAM-1 after 8 weeks of treatment.CONCLUSIONS:
By reducing leukocyte adhesion molecule expression on human endothelial cells, tibolone may have the intrinsic potential to exert additional, lipid-independent, cardiovascular protective effects that may explain the clinical benefits of cardiovascular diseases in postmenopausal women.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pós-Menopausa
/
Selectina L
/
Selectina E
/
Molécula-1 de Adesão Celular Endotelial a Plaquetas
/
Moduladores de Receptor Estrogênico
/
Norpregnenos
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article