Molecular epidemiology of HIV transmission in a dental practice.
Science
; 256(5060): 1165-71, 1992 May 22.
Article
em En
| MEDLINE
| ID: mdl-1589796
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1) transmission from infected patients to health-care workers has been well documented, but transmission from an infected health-care worker to a patient has not been reported. After identification of an acquired immunodeficiency syndrome (AIDS) patient who had no known risk factors for HIV infection but who had undergone an invasive procedure performed by a dentist with AIDS, six other patients of this dentist were found to be HIV-infected. Molecular biologic studies were conducted to complement the epidemiologic investigation. Portions of the HIV proviral envelope gene from each of the seven patients, the dentist, and 35 HIV-infected persons from the local geographic area were amplified by polymerase chain reaction and sequenced. Three separate comparative genetic analyses--genetic distance measurements, phylogenetic tree analysis, and amino acid signature pattern analysis--showed that the viruses from the dentist and five dental patients were closely related. These data, together with the epidemiologic investigation, indicated that these patients became infected with HIV while receiving care from a dentist with AIDS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pacientes
/
Infecções por HIV
/
Proteínas do Envelope Viral
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Odontologia
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article