Stochastic modeling of protein motions within cell membranes.
Phys Rev E Stat Nonlin Soft Matter Phys
; 71(4 Pt 1): 041915, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15903709
ABSTRACT
A simple model in which immobilizing events are imposed onto otherwise free Brownian diffusion [R. Metzler and J. Klafter, Phys. Rep. 339, 1 (2000) and a recent adaptation due to S. Khan and A. M. Reynolds, Physica A 350, 183 (2005)] is shown to encapsulate the peculiar transport characteristics of individual cell receptors within plasma membranes observed in single-particle tracking (SPT) experiments. These characteristics include the occurrence of normal diffusion; non-Gaussian subdiffusion; confined diffusion; a superdiffusive mode of transport that is not due to flow of the membrane or molecular motor attachment; and the occurrence of transitions between these transport modes. Model predictions are shown to be in close agreement with a reanalysis of existing SPT data.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Membrana Celular
/
Transporte Proteico
/
Antígenos HLA
/
Modelos Biológicos
/
Modelos Químicos
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article