The role of suppressors of cytokine signalling in thymopoiesis and T cell activation.
Int J Biochem Cell Biol
; 37(9): 1774-86, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-15905116
ABSTRACT
Cytokines play an essential role in mediating interactions between cells of the immune system. Suppressors of cytokine signalling proteins act to negatively regulate these cytokine signals, thereby exerting control over the expression of cytokine responsive genes. Various lines of experimental evidence suggest that two closely related members of the this family, suppressor of cytokine signalling 1 and 3, are important in the processes of T cell development, activation and homeostasis. This review outlines the principles underlying these processes and relates these to the potentially important roles played by suppressor of cytokine signalling 1 and 3.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Fatores de Transcrição
/
Ativação Linfocitária
/
Linfócitos T
/
Transdução de Sinais
/
Citocinas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article