A D-amino acid editing module coupled to the translational apparatus in archaea.
Nat Struct Mol Biol
; 12(6): 556-7, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15908961
ABSTRACT
We report the crystal structure of an archaea-specific editing domain of threonyl-tRNA synthetase that reveals a marked structural similarity to D-amino acid deacylases found in eubacteria and eukaryotes. The domain can bind D-amino acids despite a low sequence identity to other D-amino acid deacylases. These results together indicate the presence of these deacylases in all three kingdoms of life. This underlines an important role they may have played in enforcing homochirality during translation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Archaea
/
Edição de RNA
/
Aminoácidos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article