Nerve growth factor activates aorta endothelial cells causing PI3K/Akt- and ERK-dependent migration.
Pflugers Arch
; 450(5): 355-61, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-15924236
ABSTRACT
Nerve growth factor (NGF) is a well-known neurotrophin. We determined whether NGF can activate endothelial cell migration and signalling that underlie angiogenic processes. We showed that aorta endothelial cells express mRNA for both the receptor tyrosine kinase TrkA and the p75 neurotrophin receptor (p75NTR) that associates with TrkA when signalling occurs. Pig aortic endothelial cells migrated when exposed to an NGF gradient, due to the simultaneous activation of the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase signalling pathways. Furthermore, morphological changes were found in migrating cells they appear with elongated structures with a smaller cell volume than control cells. Our data show that NGF is an activator of endothelial cells and suggest that NGF plays a role in mediating angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Movimento Celular
/
Fosfatidilinositol 3-Quinases
/
Fator de Crescimento Neural
/
MAP Quinases Reguladas por Sinal Extracelular
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article