Density of Chlamydia pneumoniae is increased in fibrotic and calcified areas of degenerative aortic stenosis.
Int J Cardiol
; 108(1): 43-7, 2006 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-15925417
ABSTRACT
BACKGROUND:
The process of aortic degeneration associated with calcified aortic stenosis shares many similarities with coronary artery atherosclerosis. Inflammation and infection are involved in both diseases. Chlamydia pneumoniae has been identified in atherosclerotic plaques. However, the studies about the presence of C. pneumoniae in degenerative aortic stenotic valves are not conclusive.OBJECTIVE:
We investigated whether an association exists between the density of C. pneumoniae and fibrosis or calcification in aortic stenosis.DESIGN:
Autopsy and surgical specimens were divided into 3 groups Normal, 11 normal autopsy valves Atherosclerosis, 10 autopsy valves from patients with systemic atherosclerosis and no aortic stenosis and Aortic stenosis, 14 surgical specimens of aortic valves replaced due to aortic stenosis.SETTING:
Heart Institute (InCor), University of São Paulo Medical School. PATIENTS Aortic valves from patients aged 52+/-16 years, 69+/-9 years, and 71+/-8 years. INTERVENTION Specimens were evaluated by immunohistochemical technique (to detect C. pneumoniae antigens), in situ hybridization, and electron microscopy (to quantify the density of C. pneumoniae in the valves). MEASUREMENTS The aortic stenosis group was analyzed according to 3 subregions aortic stenosis-preserved, peripheral preserved regions; aortic stenosis-fibrosis, peri-calcified fibrotic tissue; and aortic stenosis-calcification, calcified nodules.RESULTS:
The median values of C. pneumoniae antigens were 0.09, 0.30, 0.18, 1.33, and 3.3 in groups Normal, Atherosclerosis, Aortic stenosis-preserved, Aortic stenosis-fibrosis, and Aortic stenosis-calcification, respectively. The amount of C. pneumoniae was greater in the Atherosclerosis and Aortic stenosis-calcification groups than in the Normal group (P<0.05). C. pneumoniae was greater in the Aortic stenosis group in the calcified and fibrotic regions than in preserved region (P<0.05).CONCLUSION:
An association was found between the higher density of C. pneumoniae and fibrosis/calcification in stenotic aortic valves.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estenose da Valva Aórtica
/
Calcinose
/
Infecções por Chlamydia
/
Chlamydophila pneumoniae
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article