Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities.
Eur J Med Chem
; 40(8): 737-50, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-15927308
ABSTRACT
Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Doenças Cardiovasculares
/
Desenho de Fármacos
/
Diabetes Mellitus
/
Neoplasias
/
Anti-Hipertensivos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article