A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.
Science
; 308(5727): 1480-3, 2005 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-15933203
ABSTRACT
Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
DNA Bacteriano
/
Resistência Microbiana a Medicamentos
/
Mimetismo Molecular
/
Fluoroquinolonas
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Farmacorresistência Bacteriana
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Mycobacterium tuberculosis
/
Antituberculosos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article