Acute bilateral striatal necrosis with rotavirus gastroenteritis and inborn metabolic predisposition.
Dev Med Child Neurol
; 47(6): 415-8, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15934490
ABSTRACT
We present a 9-month-old male with acute rotavirus gastroenteritis who developed an acute encephalopathy with focal seizures and developmental regression. Magnetic resonance imaging showed bilateral striatal necrosis and raised glutarylcarnitine levels on tandem mass spectrometry of a (crisis) blood spot, and chromatography of organic acids revealed increased urinary excretion of dicarboxylic acid. Skin biopsy demonstrated a partial decrease in glutaryl-CoA dehydrogenase activity. The case was not typical for either rotavirus encephalitis/rotavirus-associated encephalopathy or for glutaric aciduria type I. The patient has developmental delay and continues to receive physiotherapy, speech therapy, and local developmental follow-up.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
/
Corpo Estriado
/
Encefalopatias Metabólicas Congênitas
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Suscetibilidade a Doenças
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Gastroenterite
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article