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Carboxylate bioisosteres of gabapentin.
Burgos-Lepley, Carmen E; Thompson, Lisa R; Kneen, Clare O; Osborne, Simon A; Bryans, Justin S; Capiris, Thomas; Suman-Chauhan, Nirmala; Dooley, David J; Donovan, Cindy M; Field, Mark J; Vartanian, Mark G; Kinsora, Jack J; Lotarski, Susan M; El-Kattan, Ayman; Walters, Karen; Cherukury, Madhu; Taylor, Charles P; Wustrow, David J; Schwarz, Jacob B.
Afiliação
  • Burgos-Lepley CE; Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
Bioorg Med Chem Lett ; 16(9): 2333-6, 2006 May 01.
Article em En | MEDLINE | ID: mdl-15946842
ABSTRACT
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha2-delta protein. Further characterization of alpha2-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetrazóis / Ácidos Carboxílicos / Ácidos Cicloexanocarboxílicos / Ácido gama-Aminobutírico / Aminas / Anticonvulsivantes Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetrazóis / Ácidos Carboxílicos / Ácidos Cicloexanocarboxílicos / Ácido gama-Aminobutírico / Aminas / Anticonvulsivantes Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article