Carboxylate bioisosteres of gabapentin.
Bioorg Med Chem Lett
; 16(9): 2333-6, 2006 May 01.
Article
em En
| MEDLINE
| ID: mdl-15946842
ABSTRACT
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha2-delta protein. Further characterization of alpha2-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tetrazóis
/
Ácidos Carboxílicos
/
Ácidos Cicloexanocarboxílicos
/
Ácido gama-Aminobutírico
/
Aminas
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article