Fragmentation of trimethoprim and other compounds containing alkoxy-phenyl groups in electrospray ionisation tandem mass spectrometry.
Eur J Mass Spectrom (Chichester)
; 11(1): 73-82, 2005.
Article
em En
| MEDLINE
| ID: mdl-15947446
ABSTRACT
This work describes electrospray ionisation tandem mass spectrometry studies of trimethoprim and a series of structurally similar compounds containing alkoxy-phenyl groups; using accurate mass measurement to confirm the proposed fragmentations. Radical cations were observed in the spectra obtained for some of the compounds, as well as uncommon fragmentations showing losses of CH4 and C2H6, whereas other compounds showed the formation of even electron ions. Possible structures for the fragment ions have been proposed and explanations for the different types of fragmentations based on the structures of the compounds. In addition an alternate structure for a fragment ion previously reported for tandem mass spectrometry of trimethoprim has been proposed, based on accurate mass measurement.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trimetoprima
/
Espectrometria de Massas por Ionização por Electrospray
/
Antagonistas do Ácido Fólico
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article