Regenerative medicine: a radical reappraisal of the spleen.
Trends Mol Med
; 11(6): 271-6, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15949768
ABSTRACT
The spleen has long been considered a dispensable organ. Recent research, however, has found that the spleen of adult mice holds a reservoir of stem cells that can rapidly and robustly differentiate into functional cells of diverse lineages. Splenic stem cells express Hox11, a key embryonic transcription factor that regulates organogenesis. The presence of multi-lineage stem cells in the spleen might represent lifelong persistence of cells from a primitive embryonic region called the aorta-gonad-mesonephros. By bringing together findings from diverse disciplines, we propose that the adult spleen is an important source of multi-lineage stem cells for future cellular therapies for diabetes and other diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Baço
/
Células-Tronco
/
Medicina Regenerativa
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article