Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
Cancer Cell
; 7(6): 533-45, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15950903
ABSTRACT
RalGEFs were recently shown to be critical for Ras-mediated transformed and tumorigenic growth of human cells. We now show that the oncogenic activity of these proteins is propagated by activation of one RalGEF substrate, RalA, but blunted by another closely related substrate, RalB, and that the oncogenic signaling requires binding of the RalBP1 and exocyst subunit effector proteins. Knockdown of RalA expression impeded, if not abolished, the ability of human cancer cells to form tumors. RalA was also commonly activated in a panel of cell lines from pancreatic cancers, a disease characterized by activation of Ras. Activation of RalA signaling thus appears to be a critical step in Ras-induced transformation and tumorigenesis of human cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Proteínas Proto-Oncogênicas p21(ras)
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Proteínas ral de Ligação ao GTP
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article