Dimer-based model for heptaspanning membrane receptors.
Trends Biochem Sci
; 30(7): 360-6, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-15951182
ABSTRACT
The existence of intramembrane receptor-receptor interactions for heptaspanning membrane receptors is now fully accepted, but a model considering dimers as the basic unit that binds to two ligand molecules is lacking. Here, we propose a two-state-dimer model in which the ligand-induced conformational changes from one component of the dimer are communicated to the other. Our model predicts cooperativity in binding, which is relevant because the other current models fail to address this phenomenon satisfactorily. Our two-state-dimer model also predicts the variety of responses elicited by full or partial agonists, neutral antagonists and inverse agonists. This model can aid our understanding of the operation of heptaspanning receptors and receptor channels, and, potentially, be important for improving the treatment of cardiovascular, neurological and neuropsychyatric diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ligação Competitiva
/
Membrana Celular
/
Receptores de Superfície Celular
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article