Convergent synthesis of a complex oxime library using chemical domain shuffling.
Org Lett
; 7(13): 2751-4, 2005 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-15957938
ABSTRACT
[reaction see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Técnicas de Química Combinatória
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article