Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations.
Eur J Pharm Sci
; 26(1): 9-15, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-15970435
ABSTRACT
The effectiveness of chitosan in promoting the intranasal bioavailability of recombinant human growth hormone (hGH) has been evaluated. hGH was formulated with chitosan to produce a powder blend (Formulation A) and granules (Formulation B) for intranasal administration. The in vivo pharmacokinetic performance of the formulations was evaluated in a group of six sheep in a randomised crossover study. A subcutaneous injection of hGH solution was administered as a control. The intranasal and subcutaneous doses of hGH were 0.3 and 0.03 mg/kg, respectively. The intranasal formulations appeared to be well tolerated. Mean bioavailabilities of hGH from Formulations A and B were 14 and 15%, respectively relative to subcutaneous injection. It is concluded that chitosan-based intranasal powder formulations may provide a practical means for non-injectable delivery of hGH and, potentially, other therapeutic protein molecules.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Hormônio do Crescimento Humano
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article