Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.
Neurosci Lett
; 386(1): 18-22, 2005 Sep 23.
Article
em En
| MEDLINE
| ID: mdl-15975716
ABSTRACT
Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia. Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats. These changes were further confirmed using an enzyme-linked immunosorbent assay that confirmed downregulation of GLAST by 36% (P<0.05) and GLT-1 by 18% (P<0.05) in the L4-L5 spinal cord of taxol-treated rats. These data indicate that downregulation of glutamate transporters may contribute to the development of hyperalgesia induced by taxol and suggest that glutamate transporters may be a new target for treatment of pain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paclitaxel
/
Doenças do Sistema Nervoso Periférico
/
Células do Corno Posterior
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Sistema X-AG de Transporte de Aminoácidos
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Transportador 2 de Aminoácido Excitatório
/
Simportadores
/
Hiperalgesia
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article