Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.
Bioorg Med Chem Lett
; 15(15): 3496-500, 2005 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-15990305
ABSTRACT
A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the drug-resistant mutant viruses than they were against wild-type virus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
HIV
/
Inibidores da Protease de HIV
/
Fármacos Anti-HIV
/
Farmacorresistência Viral Múltipla
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article