"Myelodysplasia," myeloneuropathy, and copper deficiency.
Mayo Clin Proc
; 80(7): 943-6, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-16007901
ABSTRACT
We describe a patient with a suspected myelodysplastic syndrome that developed in association with a neurologic disorder resembling subacute combined degeneration but without vitamin B12 deficiency. Ultimately, the hematologic manifestations and the neurologic syndrome were linked to severe copper deficiency. Prompt and complete reversal of the hematologic abnormalities occurred with copper replacement. Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy. The hematologic picture can resemble sideroblastic anemia or myelodysplastic syndrome. Hyperzincemia can be an accompanying abnormality even without exogenous zinc ingestion. The reason for the copper deficiency may not be evident.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Debilidade Muscular
/
Cobre
/
Deficiências Nutricionais
/
Espasticidade Muscular
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article