The case of the unreliable SNP: recurrent back-mutation of Y-chromosomal marker P25 through gene conversion.
Forensic Sci Int
; 159(1): 14-20, 2006 May 25.
Article
em En
| MEDLINE
| ID: mdl-16026953
ABSTRACT
The Y-chromosomal binary marker P25 is a paralogous sequence variant, rather than a SNP three copies of the P25 sequence lie within the giant palindromic repeats on Yq, and one copy has undergone a C to A transversion to define haplogroup R1b (designated C/C/A). Since gene conversion is known to be active in the palindromic repeats, we reasoned that P25 might be liable to back-mutation by gene conversion, yielding the ancestral state C/C/C. Through analysis of a set of binary markers in Y-chromosomes in two large samples from Great Britain and the Iberian Peninsula we show that such conversion events have occurred at least twice, and provide preliminary evidence that the reverse conversion event (yielding C/A/A) has also occurred. Because of its inherent instability, we suggest that P25 be used with caution in forensic studies, and perhaps replaced with the more reliable binary marker M269.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Y
/
Medicina Legal
/
Conversão Gênica
Tipo de estudo:
Evaluation_studies
Limite:
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article