Inhibitory effect of clonidine on cholinergic transmission.
Bull Exp Biol Med
; 139(2): 198-201, 2005 Feb.
Article
em En, Ru
| MEDLINE
| ID: mdl-16027806
ABSTRACT
Equilibrium geometry and electronic structure of three local anesthetic molecules and clonidine were computed. It was shown that clonidine molecule could incorporate into local anesthetic binding centers in potential-operated Na+ channels and in ionic channels coupled to nicotinic cholinergic receptors. The modulatory effect of clonidine on contractile responses of skeletal muscle showed that blockade of Na+ channels and nicotinic cholinergic receptors is a part of its analgesic action.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clonidina
/
Transmissão Sináptica
/
Antagonistas Nicotínicos
/
Analgésicos
Limite:
Animals
Idioma:
En
/
Ru
Ano de publicação:
2005
Tipo de documento:
Article