A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group.
Org Lett
; 7(16): 3477-80, 2005 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-16048321
ABSTRACT
A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis. [structure see text]
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Nitrilas
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article